Humanin
Moderate ResearchMitochondria-derived peptide
Humanin is a 24-amino acid mitochondrial-derived peptide encoded in the 16S rRNA gene of mitochondrial DNA. It has been studied in cell biology research for its effects on cell survival signaling and its role in mitochondrial-nuclear communication. Published research has investigated its interactions with various receptor systems. RaysunPeptide supplies Humanin for qualified research and laboratory applications.
Mechanism of Action
Humanin exerts its effects through multiple mechanisms. It interacts with cell surface receptors including FPRL1 and CNTFR, activating PI3K/AKT signaling pathways that promote cell survival. It blocks pro-apoptotic proteins like Bax, reduces beta-amyloid toxicity in neurons, protects against oxidative stress, and promotes mitochondrial biogenesis. These actions support healthy cellular aging at a fundamental level.
Key Benefits
Molecular Data
Dosing Protocols
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Neuroprotection | 1-5 mg | 2-3x weekly | SubQ |
| Longevity/Anti-aging | 1-3 mg | 2x weekly | SubQ |
| HNG analog | 0.5-2 mg | 2x weekly | SubQ |
Research Indications
Neuroprotection
Originally discovered for its ability to protect against amyloid-β toxicity in neuronal cells.
Promotes mitochondrial biogenesis via PI3K/AKT signaling in PD models.
Broad neuroprotective effects against various neurotoxic insults.
Longevity
Overexpression increases lifespan in C. elegans, dependent on daf-16/Foxo pathway.
HNG analog improves metabolic healthspan parameters in middle-aged mice.
Higher levels associated with longevity in centenarians and their offspring.
Cellular Protection
Protects various cell types from stress-induced damage and death.
Blocks pro-apoptotic proteins like Bax to prevent programmed cell death.
Promotes mitochondrial function and biogenesis.
Peptide Interactions
Both are mitochondria-derived peptides with complementary longevity and metabolic benefits.
Both target mitochondrial function; may have additive benefits for cellular health.
Different mechanisms; can be combined in longevity protocols.
Both support mitochondrial function and healthy aging.
What to Expect
Side Effects & Safety
Common (Generally Mild)
- •Injection site reactions
- •Mild fatigue initially
- •Headache (rare)
Stop Signs (Seek Medical Attention)
- ⚠Signs of allergic reaction
- ⚠Unusual persistent symptoms
Contraindications
- ✕Active cancer (theoretical concern with anti-apoptotic effects)
- ✕Pregnancy or breastfeeding
- ✕Hypersensitivity to peptide components
Quality Checklist
Good Signs ✓
- White to off-white lyophilized powder
- Clear solution after reconstitution
- Intact vacuum seal
Warning Signs !
- Slight clumping that dissolves easily
Bad Signs ✕
- Discolored powder
- Cloudy or particulate solution
- Broken seal
References
Humanin overexpression extends lifespan in C. elegans; HNG treatment improves metabolic healthspan in middle-aged mice; levels higher in centenarian offspring.
Comprehensive review of humanin's neuroprotective effects in Alzheimer's and Parkinson's disease models.
Review of mitochondria-derived peptides including humanin and their roles in aging and metabolic health.
Hashimoto et al. cloned humanin from Alzheimer's patient brain; demonstrated protection against amyloid-β toxicity.
FAQs
