Melanotan I (MT-1)
FDA ApprovedSynthetic peptide analog
Melanotan I (MT-1) is a synthetic peptide analog of alpha-melanocyte stimulating hormone (α-MSH). It has been studied in research contexts for its interaction with melanocortin receptors, particularly MC1R and MC4R. Published research has examined its role in melanogenesis and pigmentation pathways in laboratory settings. RaysunPeptide supplies Melanotan I for qualified research and laboratory applications.
Mechanism of Action
Subcutaneous injection delivers peptide directly into systemic circulation. Selectively activates MC1R receptors to stimulate melanin production. Short half-life of approximately 30 minutes necessitates multiple daily dosing for sustained effect.
Key Benefits
Molecular Data
Dosing Protocols
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Loading phase | 0.25-0.5mg | 1-2x daily for 1-2 weeks | Subcutaneous |
| Maintenance | 0.25-0.5mg | 2-3x weekly | Subcutaneous |
Research Indications
Skin Health
Stimulates melanin for deeper, longer-lasting tans with reduced UV requirements
Increased melanin density provides natural UV protection and reduces sunburn
Promotes uniform melanin distribution minimizing patchy tanning
Medical Applications
FDA-approved indication for SCENESSE implant
Peptide Interactions
Overlapping mechanisms; avoid combining
Reduces required UV dose by approximately 50%
Provides additional photoprotection
Retinoids increase photosensitivity; monitor skin reactions
Enhanced monitoring recommended
What to Expect
Side Effects & Safety
Common (Generally Mild)
- •Mild nausea
- •Facial flushing
- •Reduced appetite
- •Increased mole/freckle pigmentation
Stop Signs (Seek Medical Attention)
- ⚠Severe nausea/vomiting lasting >24 hours
- ⚠Rapid concerning mole/freckle changes
- ⚠Injection site infection signs
- ⚠Unusual skin reactions
- ⚠Allergic reaction symptoms
Quality Checklist
Good Signs ✓
- Third-party HPLC testing confirming >98% purity
- Proper lyophilized powder storage
- Clear, colorless reconstitution
- Minimal side effects profile
Warning Signs !
- Check expiration dates
Bad Signs ✕
- Pre-mixed liquid solutions (degrade rapidly)
- Cloudy or discolored solution
References
Demonstrated significant photoprotection effects
View on PubMed →Established half-life and bioavailability parameters
View on PubMed →FAQs
Is Melanotan I more selective than Melanotan II?
Yes. Melanotan I is more selective for MC1R (melanin production) and less active on MC4R (sexual function, appetite). This means MT-I causes tanning without the strong appetite suppression or sexual side effects of MT-II, making it better if tanning is the only goal.
How fast will I see results from Melanotan I?
Initial skin darkening appears within 3-7 days with UV exposure. Peak tanning is visible by week 2-4 with consistent low-dose UV tanning. The combination of MT-I plus 50% less UV exposure than normal achieves deep tans much faster than sun exposure alone.
Can I use Melanotan I without any UV exposure?
Melanotan I stimulates melanin production, so some pigment develops without sun exposure. However, UV exposure significantly enhances the effect—ideally low-dose tanning bed or sun exposure 1-2 hours after injection maximizes the tanning response.
Does Melanotan I cause mole changes like Melanotan II?
Less commonly than MT-II, but moles and freckles can darken and potentially enlarge with MT-I use. Regular skin monitoring via self-examination is important. The risk appears lower with MT-I than MT-II due to reduced MC3R/MC4R activation.
