5-Amino-1MQ References & Studies
Below are 3 key peer-reviewed publications on 5-Amino-1MQ with direct PubMed links and study summaries.
Scientific References
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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ Biochemical Pharmacology (2018) PubMed
Diet-induced obese mice showed significant weight loss and adipocyte size reduction with 5-amino-1MQ treatment. Demonstrated that NNMT inhibition increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance.
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Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies Kannt A et al. Journal of Pharmaceutical and Biomedical Analysis (2021) PubMed
Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral) and 3.8hr (IV). Validated sensitive LC-MS/MS method for pharmacokinetic assessment supporting oral administration viability.
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Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice Neelakantan H et al. Scientific Reports (2024) PubMed
NNMTi-treated aged sedentary mice showed ~40% greater grip strength than controls. Combined with exercise, 60% grip strength increase. Also improved intramuscular lipid content and gastrocnemius fiber cross-sectional area.
Related Sections
- Overview: What Is 5-Amino-1MQ?
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